What would you expect from a business that makes tile designs? This sign/mural is on the west wall of 450 N. 6th Avenue, but the business is farther east along the south side of the building.
Their mosaic-style murals are all over Tucson. If you'd like to try your hand at tilework, they also offer workshops. There's more at SantaTheresaTileWorks.com.
I took the photo on February 20th.